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Nelson Textbook of Pediatrics 18th Edition Table of Contents Part I: The Field of Pediatrics 1 Overview of Pediatrics Richard E. Behrman and Bonnie Stanton 2 

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The loss of red blood cell elasticity is central to the pathophysiology of sickle cell disease. Normal red blood cells are quite elastic and have a biconcave disc shape, which allows the cells to deform to pass through capillaries.

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